Figure 4.

Thioflavin S and aggresome staining increase and co-localize in aged mouse brain. (A) Confocal microscopy of histological sections of mouse brain at different ages co-stained with Thioflavin S (green) and aggresome dye (red). Scale bar: 10 μm; Quantification of the percentage of area stained by Thioflavin S (B) and aggresome (C) dye in histological sections of mouse brain. Young (3 m.o.), adult (12 m.o.), and old (22 m.o.), n = 3 (an average of 20 slides per animal were analyzed). One way ANOVA, Tukey post-hoc test, ^nsp > 0.05, ^*p ≤ 0.05, ^**p ≤ 0.01, and ^***p ≤ 0.001. Average ± SEM.