Optimizing the reaction conditions of catalytic one-pot reaction amines with aldehydesa.
| ||||
|---|---|---|---|---|
| Entry | Substrate | Conv. (%) | c Sel. (%) | d Sel. (%) |
| 1 |
|
>99 | — | >99 |
| 2 |
|
>99 | — | >99 |
| 3 |
|
>99 | — | >99 |
| 4 |
|
>99 | 4 | 96 |
| 5 |
|
>99 | — | >99 |
| 6 |
|
>99 | — | >99 |
| 7 |
|
>99 | — | >99 |
| 8 |
|
>99 | — | >99 |
| 9 |
|
>99 | — | >99 |
| 10 |
|
>99 | — | >99 |
| 11 |
|
>99 | — | >99 |
Reaction conditions: 25 °C, atmospheric pressure, 5 mg catalyst, 0.5 mmol aldehydes, 1 mmol amines, 3 mL EtOH, H2 balloon, reaction time: 1 h.