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. 2023 Feb 8;20:29. doi: 10.1186/s12974-022-02671-z

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© The Author(s) 2023

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 4 — Increase of NF-L in plasma from TREM2-sol and TREM2-KO in the acute cuprizone model. NF-L measurements in plasma of WT, TREM2-IPD, TREM2-sol and TREM2-KO mice receiving control food (ctrl), at 5 weeks of cuprizone intoxication (cpz) and at 4-week recovery on normal food (rec). Group sizes: wt ctrl (n = 4), wt cpz (n = 4), wt rec (n = 4), TREM2-IPD ctrl (n = 3), TREM2-IPD cpz (n = 7), TREM2-IPD rec (n = 7), TREM2-sol ctrl (n = 4), TREM2-sol cpz (n = 7), TREM2-sol rec (n = 4), TREM2-KO cpz (n = 4). One-way ANOVA Holm–Šídák's multiple comparisons test, *p < 0.05, ***p < 0.001, ****p < 0.0001. Comparisons not indicated are non-significant. Wt ctrl1, wt cpz1 and wt rec1 are the respective wild-type groups for the study with TREM2-IPD and TREM2-sol, wt ctrl2, wt cpz2 and wt rec2 are the wild-type groups for the TREM2-KO study. Only statistical analysis within a study was performed