Table 2.
Parasitological, haematological and biochemistry characteristics of the NeuroCM study population
| Factors | Overall n = 70 |
Surviving children n = 50 |
Deceased children n = 20 |
P-valuea |
|---|---|---|---|---|
| P. falciparum density /µl of blood, median (IQR) |
74,800 (12,425–421,278) |
45,000 (4940–317,250) |
296,000 (32,590–684,190) |
0.09 |
| Haemoglobin level in g/dL, mean (± SD) | 5.8 (± 2.2) | 5.9 (± 2.1) | 5.7 (± 2.6) | 0.71 |
| Haemoglobin level < 11, % (n) | 97.1 (68) | 98.0 (49) | 95.0 (19) | 0.55 |
| Hematocrit, mean (± SD) | 17.1 (± 6.9) | 17.4 (± 6.4) | 16.6 (± 8.0) | 0.42 |
| Leucocytes × 103/µl, mean (± SD) | 16.8 (± 11.3) | 15.9 (± 11.6) | 18.7 (± 10.0) | 0.04 |
| Lymphocytes × 103/µl, mean (± SD) | 5.7 (± 4.5) | 5.3 (± 4.7) | 6.7 (± 3.5) | 0.01 |
| Monocytes × 103/µl, mean (± SD) | 0.9 (± 0.8) | 0.9 (± 0.9) | 1.2 (± 0.6) | 0.004 |
| Neutrophils × 103/µl, mean (± SD) | 9.9 (± 7.1) | 9.6 (± 6.7) | 10.5 (± 7.9) | 0.62 |
| Eosinophils × 103/µl, mean (± SD) | 0.2 (± 0.2) | 0.2 (± 0.2) | 0.2 (± 0.2) | 0.64 |
| Basophils × 103/µl, mean (± SD) | 0.001 (± 0.01) | 0.002 (± 0.01) | 0 | 0.90 |
| Thrombocytes × 103/µl, mean (± SD) | 111.5 (± 98.3) | 105.04 (± 82.7) | 131.3 (± 137.5) | 0.99 |
| Glucose in g/L, mean (± SD) | 0.8 (± 0.7) | 0.9 (± 0.7) | 0.5 (± 0.5) | 0.07 |
| Glucose < 0.4 g/L, % (n) | 35.7 (25) | 22.0 (11) | 70.0 (14) | 0.17 |
| Urea in g/L, mean (± SD) | 0.2 (± 0.2) | 0.2 (± 0.1) | 0.3 (± 0.3) | 0.09 |
| Creatinine in mg/L, mean (± SD) | 6.2 (± 7.2) | 4.8 (± 3.5) | 10.2 (± 12.3) | 0.02 |
SD: Standard deviation; IQR Interquartile range
aMann‒Whitney U test for quantitative variables, Pearson’s Chi2 test for qualitative variables
P-values in bold are < 0.05