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. 2023 Jan 16;19(3):967–980. doi: 10.7150/ijbs.76407

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PTEN, MMP2, and MMP9 are downstream targets of BC002811. (A) Venn diagram of overlapping genes obtained from differentially expressed mRNAs displaying the opposite trend between the BC002811-overexpression group and the BC002811-shRNA group in human tumor metastasis qPCR arrays assay. (B) qPCR analysis of PTEN, MMP2, and MMP9 expression in AGS and HGC-27 cells after knockdown or overexpression of BC002811. (C) PTEN, MMP2, and MMP9 protein levels in AGS and HGC-27 cells by western blot after knockdown or overexpression of BC002811. (D) Representative IHC staining images of PTEN, MMP2, and MMP9 in subcutaneous tumor xenograft tissues. Scale bar, 100 μm. Data expressed as mean±SD. **P <0.01.