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. 2023 Jan 16;19(3):967–980. doi: 10.7150/ijbs.76407

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BC002811 promotes GC cell migration and invasion in part by regulating PTEN. (A) Transwell^® migration and invasion assays were carried out in PTEN-upregulated AGS and HGC-27 cells with overexpression of BC002811. Scale bar, 10 μm. qPCR (B) and western blot (C) analyses were performed to determine MMP2 and MMP9 expression after upregulation of BC002811 in PTEN-overexpressing AGS and HGC-27 cells. (D) Gelatin zymography was used to determine the MMP2 and MMP9 enzymatic activity in AGS and HGC-27 cells. (E) Statistical analysis of the gelatin zymography results. Data expressed as mean±SD. *P < 0.05, **P <0.01.