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. 2023 Jan 16;19(3):967–980. doi: 10.7150/ijbs.76407

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This is an open access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/). See http://ivyspring.com/terms for full terms and conditions.

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Proposed model for BC002811 regulation of PTEN expression and GC metastasis. BC002811 competitively SOX2 interaction with the PTEN promoter. This leads to suppression of PTEN transcription and promotion of MMP2 and MMP9 expression, thereby exerting its pro-metastatic role in GC.