Table 4.
Cox regression analysis evaluating pre-existing conditions associated with disease severity.
| Clinical characteristics | Univariate |
Multivariate |
||
|---|---|---|---|---|
| HR | p-value | Adjusted HR | p-value | |
| Sex (male) | 1.23 (0.89–1.70) | 0.209 | 1.14 (0.82–1.59) | 0.440 |
| Age category (years) | ||||
| 18–39 | 1 (ref) | 1 (ref) | ||
| 40–49 | 2.96 (1.53–5.74) | 0.001∗ | 2.43 (1.25–4.74) | 0.009∗ |
| 50–59 | 3.20 (1.70–6.02) | <0.001∗ | 2.33 (1.21–4.48) | 0.011∗ |
| 60–69 | 4.82 (2.58–9.01) | <0.001∗ | 3.65 (1.91–6.96) | <0.001∗ |
| ≥70 | 8.10 (4.27–15.35) | <0.001∗ | 5.70 (2.91–11.14) | <0.001∗ |
| Comorbidity present (any) | 1.87 (1.31–2.66) | <0.001∗ | 1.44 (0.98–2.10) | 0.064 |
| Time from illness onset to hospital admission, days∗ | ||||
| ≤7 | 1 (ref) | 1 (ref) | ||
| 8–14 | 0.61 (0.40–0.93) | 0.022∗ | 0.61 (0.40–0.93) | 0.022∗ |
| >14 | 0.64 (0.31–1.32) | 0.228 | 0.59 (0.29–1.21) | 0.147 |
COVID-19, coronavirus disease 2019; HR, hazard ratio; ∗, statistically significant (p-value <0.05).