Extended Data Table 1 |.
Patient demographics and clinical information for cohort 1 (left), cohort 2 (middle) and combined cohorts (right).
| Cohort 1 NF (N=18) | Cohort 1 DCM (N=18) | Cohort 1 p-val | Cohort 2 NF (N=30) | Cohort 2 DCM (N=21) | Cohort 2 p-val | Combined NF (N=48) | Combined DCM (N=39) | Combine d p-val | |
|---|---|---|---|---|---|---|---|---|---|
| Age (yrs) | 51.0 ± 9.7 | 52.1 ± 10.9 | 0.76 | 56.3 ± 11.5 | 50.9 ± 11.6 | 0.11 | 54.3 ± 11.1 | 51.5 ± 11.3 | 0.2 |
| Male (%) | 8(44) | 10(55) | 15(48) | 12(57) | 23(48) | 22(56) | |||
| Caucasian (%) | 10(56) | 9(50) | 27(87) | 14(67) | 37(77) | 23(59) | |||
| Weight (kg) | 81.8 ± 19.4 | 80.8 ± 15.0 | 0.87 | 82.0 ± 20.0 | 82.0 ± 19.0 | 1.0 | 81.9 ± 19.8 | 81.5 ± 17.3 | 0.9 |
| Height (cm) | 167.1 ± 9.3 | 173.3 ± 10.3 | 0.071 | 170.9 ± 10.0 | 169.7 ± 9.3 | 0.7 | 169.5 ± 9.9 | 171.4 ± 10.0 | 0.4 |
| BMI (kg/m2) | 29.2 ± 6.1 | 26.8 ± 3.6 | 0.17 | 28.2 ± 7.5 | 28.2 ± 5.0 | 1.0 | 28.6 ± 7.0 | 27.6 ± 4.5 | 0.4 |
| Heart Weight (g) | 377.3 ± 80.8 | 475.9 ± 106.1 | 0.0044 | 365.5 ± 98.0 | 475.7 ± 139.9 | 0.009 | 369.9 ± 91.2 | 466.1 ± 125.8 | 0.0001 |
| LV Mass (g) | 216.2 ± 46.5 | 301.8 ± 81.4 | 0.0072 | 216.7 ± 51.7 | 297.6 ± 97.2 | 0.00044 | 216.6 ± 50.1 | 298.8 ± 93.1 | 8.1E-06 |
| LVMI | 107.5 ± 15.6 | 154.3 ± 43.8 | 0.0026 | 110.2 ± 19.8 | 150.9 ± 39.6 | 1.9E-05 | 109.4 ± 18.6 | 151.8 ± 40.8 | 9.8E-08 |
| LVEF (%) | 65.7 ± 8.2 | 10.5 ± 3.7 | 1.15E-23 | 64.3 ± 7.0 | 15.9 ± 6.1 | IE-29 | 64.8 ± 7.5 | 13.4 ± 5.8 | 5E-52 |
| LVEDD (cm) | 4.3 ± 0.2 | 7.6 ± 1.3 | 0.0015 | 4.2 ± 0.6 | 7.0 ± 1.1 | 2E-12 | 4.2 ± 0.6 | 7.2 ± 1.2 | 4E-16 |
| LVESD (cm) | 2.4 ± 0.4 | 7.0 ± 1.2 | 4.5E-05 | 2.7 ± 0.8 | 6.4 ± 1.2 | 2E-14 | 2.7 ± 0.5 | 6.6 ± 1.3 | 1E-20 |
| PW Thickness (cm) | 1.1 ± 0.2 | 0.86 + 0.2 | 0.10 | 1.0 ± 0.2 | 0.9 ± 0.2 | 0.01 | 1.0 ± 0.2 | 0.9 ± 0.2 | 0.001 |
| h/o VT/VF (%) | 0(0) | 11(61) | 0(0) | 14(67) | 0(0) | 25(64) | |||
| h/o ChrAfib (%) | 0(0) | 4(22) | 4(13) | 15(71) | 4(9) | 19(49) | |||
| h/o Htn (%) | 8(44) | 4(22) | 14(45) | 20(95) | 22(46) | 24(62) | |||
| Creatinine | 1.9 ± 2.3 | 1.5 ± 0.8 | 0.60 | 1.5 ± 1.2 | 1.0 ± 0.2 | 0.09 | 1.6 ± 1.7 | 1.2 ± 0.5 | 0.1 |
P values determined by two-sided Student’s t-test between combined cohort failing and nonfailing samples. LVMI, left ventricular mass index; LVEF, left ventricular ejection fraction; LVEDD, left ventricular end-diastolic diameter; LVESD, left ventricular end-systolic diameter; PW, posterior wall; h/o, history of; VT/VF, ventricular tachycardia/ventricular fibrillation; ChrAfib, chronic atrial fibrillation; Htn, hypertension.