FIG. 1.

Plasma TFV and FTC Exposures. Plasma exposures (AUC_tau) of TFV and FTC are shown [as geometric mean, GM (95% CI)] for the overall study population, and among TW and TM. Shown in black are previously published AUC values among cisgender participants from separate studies. Unless otherwise labeled, they are expressed as GM (95% CI).^4,6,7,9 Hiransuthikul et al.⁷ reported TFV GM AUC (CV%); this was converted to GM (95% CI); FTC exposures were not reported for this study. The Cell-PrEP study⁹ reported mean (95% CI) C_ss, which was calculated as AUC/24 h; mean (95% CI) AUC was then determined for comparison here as reported C_ss × 24 h. AUC, area under the curve; CI, confidence interval; FTC, emtricitabine; GM, geometric mean; GMR, geometric mean ratio; PrEP, pre-exposure prophylaxis; TFV, tenofovir; TM, transgender men; TW, transgender women.