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. 2023 Feb 9;11(2):e779. doi: 10.1002/iid3.779

Figure 1.

Figure 1

Ovalbumin induced allergic airway inflammation was inhibited in progranulin‐deficient mice. (A) Numbers of inflammatory cells in BALF of WT and PGRN KO mice induced (or not) by OVA. Results were shown as means ± SD. (WT PBS, n = 11, WT OVA, n = 12, PGRN KO PBS, n = 11, PGRN KO OVA, n = 9) **p < .01; ****p < .0001, Welch's t‐test. (B) Th2 cytokines IL‐4 and IL‐5 in lung homogenates measured by ELISA. Data were presented as means ± SD. (WT PBS, n = 4, WT OVA, n = 4, PGRN KO PBS, n = 3, PGRN KO OVA, n = 4). *p < .05; **p < .01, Welch's t‐test for IL‐4, unpaired t test for IL‐5. (C) Representative images of H&E and PAS staining lung tissue showing pathological alterations (arrowheads) and semi‐quantified score (D). Scale bar: 100 μm. The study was repeated for three times. BALF, bronchoalveolar lavage fluid; H&E, hematoxylin and eosin; KO, knockout; PAS, Periodic Acid‐Schiff; PBS, phosphate‐buffered saline.