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. 2023 Jan 26;13:1044592. doi: 10.3389/fimmu.2022.1044592

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Copyright © 2023 Mendonca, Pernet, Khan, Sanz, Kaufmann, Downey, Grant, Orlova, Schurr, Krawczyk, Jones, Barreiro and Divangahi

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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A virulent strain of Mtb inhibits the glycolytic pathway in both AM and BMDM M1/M2 bone marrow-derived and naïve alveolar macrophages were subjected to a Seahorse assay to measure cellular metabolism before and after 24hrs of infection with H37Rv at MOI of 1. (A, B) Quantification of basal OCR (A) and ECAR (B) in macrophages infected with H37Rv. (C) M1 and M2 bone marrow-derived and naïve alveolar macrophages were infected at MOI 1 with H37Rv and subjected to CFU assays. Data are given as mean ± SEM. The data are representative of 4 (A, B) or 3 (C) independent experiments. *p<0.05; **p<0.01; ***p<0.001, ****p<0.0001 determined by 2-way ANOVA followed by Tukey’s or Sidak’s multiple comparison.