Table 2.
SNP Associations with p<10−6 from Meta-Analysis and Ancestry-Specific Genome-Wide Association Studies.
| SNP | Chromosome: position | Alleles eff/alt | p-value | Odds Ratio (SE) | Annotation | Replication |
|---|---|---|---|---|---|---|
| * Meta-Analysis Results (14089 (3.4%) cases, 395064 (96.6%) controls) | ||||||
| rs56817213 | 20: 51818256 | A/G | 3.64×10−9 | 1.22 (0.03) | TSHZ2 | |
| rs72730526 | 1: 218026968 | A/T | 3.69×10−8 | 1.21 (0.03) | SPATA17 | 6.75×10−1 |
| rs10407501 | 19: 30569741 | A/G | 5.41×10−8 | 1.23 (0.04) | URI1, ZNF536 | |
| rs116165183 | 8: 138806806 | A/G | 7.25×10−8 | 1.35 (0.06) | LOC101927915, LOC401478 | |
| rs12883260 | 14: 56398379 | A/G | 1.62×10−7 | 1.11 (0.02) | LINC00520, PELI2 | 9.44×10−1 |
| rs6589377 | 11: 113355736 | A/G | 1.77×10−7 | 0.93 (0.01) | DRD2, TMPRSS5 | 7.97×10−4 |
| rs1107162 | 11: 113289037 | A/G | 2.16×10−7 | 0.93 (0.01) | DRD2 | 2.52×10−5 |
| rs28731324 | 14: 61747119 | C/G | 2.28×10−7 | 1.20 (0.04) | TMEM30B | |
| European American Results ( 9196 (3.1%) cases, 287370 (96.9%) controls) | ||||||
| rs4858820 | 3: 48484016 | T/A | 3.20×10−8 | 1.10 (0.02) | ATRIP | 1.73×10−1 |
| rs202061221 | 3: 48412264 | CG/C | 3.10×10−7 | 1.10 (0.02) | SPINK8, FBXW12 | 1.23×10−1 (rs56023037) |
| rs555562525 | 11: 113318196 | GA/G | 4.80×10−7 | 0.91 (0.02) | DRD2 | 1.89 × 10−4 (rs17601612) |
| rs376014007 | 19: 51031620 | C/T | 5.10×10−7 | 1.09 (0.02) | LRRC4B | 5.66×10−2 |
| rs360210 | 9: 127797945 | C/T | 6.39×10−7 | 0.92 (0.02) | SCAI | 3.94×10−2 |
| rs2174168 | 5: 62971367 | A/T | 6.44×10−7 | 1.08 (0.02) | IPO11, HTR1A | 3.50 ×10−1 (rs2365873) |
| African American Results (3507 (4.5%) cases, 74306 (95.5%) controls) | ||||||
| rs56817213 | 20: 51818256 | G/A | 1.38×10−8 | 1.22 (0.04) | TSHZ2 | |
| rs116165183 | 8: 138806806 | G/A | 2.90×10−8 | 1.37 (0.06) | LOC101927915, LOC401478 | |
| rs28731324 | 14: 61747119 | C/G | 1.46×10−7 | 1.21 (0.04) | TMEM30B | |
| rs536061513 | 9: 131007176 | C/A | 3.16×10−7 | 1.82 (0.12) | DNM1 | |
| rs34326041 | 8: 19193436 | T/G | 3.50×10−7 | 1.18 (0.03) | SH2D4A | 6.70×10−1 |
| rs3796820 | 4: 10097446 | A/G | 3.59×10−7 | 1.58 (0.09) | WDR1 | 4.72×10−2 |
| rs75861007 | 14: 61730115 | G/T | 3.60×10−7 | 1.32 (0.05) | SNORD112 | |
| rs114579897 | 5: 83946735 | T/G | 4.10×10−7 | 2.26 (0.16) | EDIL3, NBPF22P | 2.42 × 10−2 (rs78097367) |
| rs369284963 | 16: 7462413 | C/CA | 8.58×10−7 | 1.15 (0.03) | RBFOX1 | 9.98 ×10−2 (rs8050278) |
| rs61859846 | 10: 131294704 | C/A | 8.67×10−7 | 1.21 (0.04) | MGMT | 3.09×10−1 |
| rs56291711 | 4: 190043389 | T/C | 9.89×10−7 | 0.87 (0.03) | LINC02508, LINC01262 | 9.85.x10−2 (rs57050950) |
| Hispanic American Results (1271 (4.2%) cases, 29306(95.8%) controls) | ||||||
| rs34173987 | 3: 54892449 | G/A | 1.76×10−8 | 2.34 (0.15) | CACNA2D3 | |
| rs6907713 | 6: 120589671 | C/A | 2.08×10−8 | 15.67 (0.49) | MIR3144, TBC1D32 | |
| rs9596440 | 13: 51646178 | G/C | 3.17×10−8 | 2.73 (0.18) | GUCY1B2 | |
| Asian American Results (115 (2.7%) cases, 4082 (97.3%) controls) | ||||||
| rs199633759 | 15: 48822272 | A/G | 2.20×10−8 | 2.77 (0.18) | FBN1 | |
| rs77378519 | 15: 48831864 | C/T | 2.89×10−8 | 2.69 (0.18) | FBN1 | |
| rs57790277 | 15: 48855753 | T/C | 2.98×10−8 | 3.07 (0.20) | FBN1 | |
*
For the meta-analysis, the direction of effects were (EA AA HA AS): rs56817213 (- - - -), rs72730526 (+ + + +), rs10407501 (+ + + +), rs116165183 (- - + -), rs12883260 (+ - + +), rs6589377 (+ - + +), rs1107162 (- + - -), rs28731324 (+ - + -).