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. Author manuscript; available in PMC: 2023 Apr 1.
Published in final edited form as: Nat Genet. 2022 Sep 29;54(10):1479–1492. doi: 10.1038/s41588-022-01187-9

Extended Data Fig. 10. Analysis of disease-dependent programs across all tissues and traits.

Extended Data Fig. 10.

Magnitude (E-score, dot size) and significance (−log10(P-value), dot color) of the heritability enrichment of disease-dependent programs (columns) from UC, MS, Alzheimer’s, asthma and pulmonary fibrosis (labels on top, color code, legend), for GWAS summary statistics of diverse traits and diseases (rows), based on the Roadmap∪ABC enhancer-gene linking strategy for the corresponding tissue. Details for all traits analyzed are in Supplementary Table 2. See Data Availability for higher resolution version of this figure.