Figure. 2.

Representative renal transporters that are responsible for secretion and reabsorption in proximal tubule cells. Transporters on the basolateral membrane transport molecules from the blood into the proximal tubule cells. Apical transporters are responsible for the efflux of molecules from the proximal tubule cells into the urinary ultrafiltrate. Some transporters work bi-directionally and reabsorb certain molecules from the ultrafiltrate back into the blood. UT: urea transporter; OAT: organic anion transporter; MATE: multidrug and toxin extrusion protein; MRP: multidrug resistance-associated protein; P-gp: P-glycoprotein; URAT: urate transporter; SGLT: sodium-glucose co-transporter; OCT: organic cation transporter.