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. Author manuscript; available in PMC: 2023 Mar 1.
Published in final edited form as: J Mol Cell Cardiol Plus. 2022 Nov 29;3:100024. doi: 10.1016/j.jmccpl.2022.100024

Fig. 3.

Fig. 3.

Echocardiography measurement in conscious mice 5 weeks post-MI. A) Representative M-mode echocardiography on conscious mice given either vehicle or Ac-SDKP for 5 weeks after MI. IS indicates interventricular septum; DD, LV diastolic dimension; and PW, LV posterior wall. B) and C) Left ventricular shortening fraction (SF) and ejection fraction (EF) in mice treated with or without Ac-SDKP, respectively. Left ventricular chamber dilation and markedly reduced EF and SF were exhibited in mice with MI, ACE-NKO mice had significantly better cardiac performances. Both EF and SF were improved by Ac-SDKP treatment in WT mice but were not further improved in ACE-NKO mice. The number of experiments was as follows: SF; WT-Sham (n = 13), WT- MI+ vehicle (n = 16), WT- MI + Ac-SDKP (n = 21), ACE-NKO-Sham (n = 16), ACE-NKO- MI+ vehicle (n = 26), ACE-NKO- MI + Ac-SDKP (n = 12); EF; WT-Sham (n = 14), WT- MI+ vehicle (n = 15), WT- MI + Ac-SDKP (n = 20), ACE-NKO-Sham (n = 12), ACE-NKO- MI+ vehicle (n = 17), ACE-NKO- MI + Ac-SDKP (n = 12). *p < 0.05 vehicle vs sham; **p < 0.001 Ac-SDKP vs vehicle (By Student’s t-tests with Satterthwaite correction for unequal variance).