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. Author manuscript; available in PMC: 2023 Mar 1.
Published in final edited form as: J Mol Cell Cardiol Plus. 2022 Nov 29;3:100024. doi: 10.1016/j.jmccpl.2022.100024

Fig. 5.

Fig. 5.

The protein expression analyzed by immunoblot in left ventricular (LV) tissue homogenates in WT vs. ACE-NKO in mice after 5 weeks post-MI for SERCA2 (A & C) and PLB (B & D). ACE-NKO mice protected the loss of SERCA2 expression compared to WT mice subjected to MI. The loss of SERCA2 expression in WT mice after 5 weeks post-MI, was significantly recovered with exogenous supplementation of Ac-SDKP. In contrast, PLB expression in sham was significantly higher in WT compared to ACE-NKO without any changes after 5 weeks of post-MI in between the two groups. (E) The ratio PLB/SERCA2 shows a significant increase in both sham and MI WT groups compared to ACE-NKO mice; administration of Ac-SDKP significantly normalized PLB/SERCA2 ratio. The number of experiments repeated was n = 4/group; *p ≤ 0.05, **p < 0.001 (By Student’s t-tests with Satterthwaite correction for unequal variance).