. Author manuscript; available in PMC: 2023 Mar 1.

Published in final edited form as: J Mol Cell Cardiol Plus. 2022 Nov 29;3:100024. doi: 10.1016/j.jmccpl.2022.100024

Table 1.

Echocardiographie and body weight measurements 5 weeks post-MI.

Parameters	WT			ACE-N KO
Parameters	Sham	MI + Vehicle	MI + Ac-SDKP	Sham	MI + Vehicle	MI + Ac-SDKP

BW, g	26.75 ± 0.54	26.63 ± 0.67	27.74 ± 0.52	25.07 ± 0.66	27.09 ± 0.36^*	25.11 ± 0.79
LVM, mg/10 g BW	21.36 ± 0.83	46.77 ± 3.67^*	40.09 ± 3.76^*	24.66 ± 0.66	48.82 ± 3.14^*	54.14 ± 7.00^*
LVW, mg/10 g BW	34.48 ± 1.73	47.69 ± 3.23^*	49.10 ± 3.19	38.88 ± 0.89	50.73 ± 1.70^*	54.88 ± 1.51
Infarcted area (%)	None	35.0 ± 0.020	37.0 ± 0.023	None	39.0 ± 0.021	37.0 ± 0.022
PWTd, mm	0.83 ± 0.02	0.85 ± 0.02	0.87 ± 0.02	0.85 ± 0.01	0.90 ± 0.01^*	0.92 ± 0.02^*
LVDd, mm	2.47 ± 0.03	4.04 ± 0.16^*	3.45 ± 0.14^*^,†	2.50 ± 0.03	3.95 ± 0.17^*	4.11 ± 0.29^*
LVAd, mm²	4.11 ± 0.14	17.95 ± 1.96^*	12.84 ± 1.76^†	4.23 ± 0.14	15.00 ± 1.68^*	18.11 ± 2.99
HR, beats/min	684 ± 9	650 ± 16	658 ± 8	665 ± 12^¥	614 ± 14	576 ± 23^‡

Values are means ± standard error. MI, myocardial infarction; LVDd, left ventricular diastolic dimension; LVAd, left ventricular diastolic area; PWTd, diastolic posterior wall thickness; LVW, left ventricular weight, measured by gravimetry; LVM, left ventricular mass, measured by echocardiography; HR, heart rate; BW, body weight.

p < 0.005, vs sham within WT or ACE-N KO.

^†

p < 0.05 vs MI within WT.

^¥

p = 0.018 vs MI within ACE-N KO.

^‡

p < 0.005

WT vs ACE-NKO for MI + Ac-SDKP. The number of experiments was as follows: BW, LVM, PWTd, LVDd, LVAd and HR: (WT/ACE-NKO - Sham; n = 13), (WT/ACE-NKO - MI+ Vehicle; n = 15), (WT/ACE-NKO - MI + Ac-SDKP; n = 20); LVW: (WT - Sham; n = 9), (WT - MI+ Vehicle; n = 13), (WT - MI + Ac-SDKP; n = 15); LVW: (ACE-NKO - Sham; n = 15), (ACE-NKO - MI+ Vehicle; n = 16), (ACE-NKO - MI + Ac-SDKP; n = 26).