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. 2023 Jan 11;223(2):iyac176. doi: 10.1093/genetics/iyac176

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Fig. 3. — Signaling molecules that specify spatial arrangement of DA9 neuromuscular junctions. a) UNC-6/Netrin, LIN-44/Wnt and EGL-20/Wnt form gradient distribution around DA9 to prevent the assembly of synapses. b) PLX-1/Plexin and their effectors locally inhibit presynaptic assembly in the distal axon. In the posterior axonal region, Wnt-bound LIN-17/Frizzled inhibits presynaptic assembly, while Wnt-unbound LIN-17 instructs synapse formation within the presynaptic domain. c) In the dendrite, UNC-5 inhibits presynaptic assembly.