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. 2022 Dec 28;120(1):e2213099120. doi: 10.1073/pnas.2213099120

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Copyright © 2022 the Author(s). Published by PNAS.

This article is distributed under Creative Commons Attribution-NonCommercial-NoDerivatives License 4.0 (CC BY-NC-ND).

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Fig. 4. — Low-frequency-specific hearing loss in 4-wk-old Fst cKO mutants. (A–C) ABR analyses of 4-wk-old Fst^lox/lox and Pax2-Cre; Fst^lox/lox mice. ABR thresholds of Fst^lox/lox and Pax2-Cre; Fst^lox/lox mice to click stimuli and individual frequencies (A). I/O function analyses of wave I amplitudes from the ABRs to low (6 kHz) and high (18 kHz) frequencies (B, C). (D–F ) DPOAE analyses of 4-wk-old Fst^lox/lox and Pax2-Cre; Fst^lox/lox mice. 2f₁-f₂ DPOAE thresholds of Fst^lox/lox and Pax2-Cre; Fst^lox/lox mice (D). DPOAE I/O function analyses at 6 kHz and 18 kHz (E, F ). Data are presented as means ± SE. Statistical comparisons were determined via two-way ANOVA with Bonferroni corrections for multiple comparisons (n.s., non-significant, *P < 0.05, **P < 0.01, and ***P < 0.001).