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Schematic diagram depicting the cardiac and extra-cardiac impacts of RGS7 following induction by chemotherapeutic drugs. Chemotherapeutic drugs lead to induction of RGS7/CaMKII in both ECs and ventricular cardiac myocytes. In VCM, RGS7 promotes oxidative stress, mitochondrial dysfunction, and cell death as well as the release of cardiokines that drive cardiac fibrosis and loss of ventricular integrity.
