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. 2022 Dec 27;120(1):e2214757120. doi: 10.1073/pnas.2214757120

Fig. 3.

Fig. 3.

(A) Schematic diagram of the characteristics of HCC tumor, including leaky tumor vasculature and dense ECM. (B) Schematic representation of an impaired vasculature model using a transwell insert with a TNF-α-treated HUVECs layer and (C) The Confocal Laser Scanning Microscopy (CLMS) images of HUVECs with or without TNF-α treated. (Scale bar, 10 µm.) (D) Schematic representation of a transwell model with a HUVEC layer and Huh-7 cells (E) Cell uptake of DiI-encapsulated PEGylated SNs and MCSNs by Huh-7 liver cancer cells analyzed by flow cytometry of (D) model. (F) Schematic representation of a transwell model with Huh-7 cells dispersed in collagen (G) Cell uptake of DiI-encapsulated PEGylated SNs and MCSNs by Huh-7 liver cancer cells analyzed by flow cytometry of (F) model.