Fig 1. PPI quality control pipeline for LRRK2 interactome construction.

Human PPI data downloaded from PINOT, HIPPIE and MIST databases were merged after ID conversion using HGNC gene symbols. Merged data underwent interaction detection method reassignment using an in-house dictionary. Publication score (PS) was defined as the number of papers in which a PPI was reported, while method score (MS) was defined as the number of different methods by which a PPI was detected. Final score (FS) was calculated as PS + MS. PPIs with FS ≤ 2 were excluded from further analysis.