Table 3.
The characteristics of patients.
| Study | Year | Mean Age | Mean/Median EDSS | Course of disease | Subtypes | ||||
|---|---|---|---|---|---|---|---|---|---|
| Exp | Ctrl | Exp | Ctrl | Exp | Ctrl | Exp | Ctrl | ||
| Cognition | |||||||||
| Charvet et al. (21) | 2018 | 52.69 | 51.00 | - | - | 17.71 | 15.70 | 7RR 18 OS | 15RR 5 OS |
| Simani et al. (22) | 2022 | 30.60 | 34.8 | - | - | 4.86 | 4.61 | 20RR | 20RR |
| Hanken et al. (23) | 2016 | 51.35 | 46.8 | 4.4 | 3.95 | - | - | 8RR 12CP | 7RR 13CP |
| Fiene et al. (24) | 2018 | 43.20 | 3.54 | 9.63 | 14RR 1OS | ||||
| Palm et al. (25) | 2016 | 47.4 | 4.2 | 12.5 | 11RR 1SP 4PP | ||||
| Chalah et al. (26) | 2016 | 40.50 | 2.3 | 14.0 | 9RR 1SP | ||||
| Ayache et al. (27) | 2016 | 48.9 | 4.25 | 11.8 | 11RR 4SP 1PP | ||||
| Grigorescu et al. (28) | 2020 | 43.91 | 3.14 | 75.64 Months | 10RR 1SP | ||||
| Mattioli et al. (29) | 2015 | 38.2 | 47.4 | 2.9 | 2.1 | 6.6 | 11.0 | 10RR | 10RR |
| Motor | |||||||||
| Salemi et al. (30) | 2018 | 39.8 | 44.2 | 2.8 | 2 | – | – | – | – |
| San et al. (31) | 2019 | 48.70 | 53.00 | – | – | 14.70 | 19.50 | – | – |
| Baroni et al. (32) | 2022 | 55.25 | 52.13 | 4.69 | 4.5 | 11.13 | 11.13 | 3RR 4PP 1SP | 3RR 3PP 2SP |
| Pilloni et al.A (33) | 2020 | 52.1 | 54.2 | 5.5 | 5 | – | – | – | – |
| Pilloni et al.B (34) | 2020 | 52.1 | 53.5 | 5.3 | 4.5 | – | – | 2RR 7SP | 3RR 3SP |
| Darwish et al. (35) | 2019 | 32.20 | 31.13 | 2 | 3 | – | – | 15RR | 15RR |
| Iodice et al. (36) | 2015 | 43.3 | 40.3 | 3.6 | 3.8 | 7.0 | 7.8 | 10RR | 10RR |
| Mori et al. (37) | 2011 | 39.1 | 37.7 | 3.6 | 3.8 | – | – | – | – |
Exp, Experimental group; Ctrl, Control group; EDSS, Extended Disability Status Scale; RR, Relapse-remitting multiple sclerosis; PP, Primary progressive multiple sclerosis; SP, Secondary progressive multiple sclerosis; CP, Chronic Progressive multiple sclerosis; OS, Other subtypes.