Table 2. Summary of clinical presentation and management of our case and the recent reported case of idiopathic orbital inflammation (IOI).

RTX: rituximab

IOI cases	Clinical presentation	Management
Our case	28 years old woman   Unilateral swelling in the right orbit for more than 10 years   Proptosis of the right eye and ptosis     MRI Orbit showed proptotic right eye globe with extra-conal enhancing soft tissue	3 cycles of RTX IV monotherapy
Case 1 [5]	67 years old man   Chronic swelling of the left lower eyelid   Normal visual acuity and ocular motility of the left eye   Palpable mass at the lower eyelid	1.0–1.5 mg/kg of oral prednisone per day for 1 week and taper   Intraorbital RTX at a dose of 10 mg once a week for the first month then a second complete cycle of 4 RTX IV injections
Case 2 [5]	54 years old man   Right eye proptosis, diplopia in left lateral gaze and mild ptosis   Visual acuity 0.2 logMaR in the right eye   Palpable mass in thesuperotemporal orbital quadrant   Inferomedial ocular globe displacement	1.0–1.5 mg/kg of oral prednisone per day for 2 weeks and taper   Intraorbital RTX at a dose of 10 mg, followed by a complete cycle of RTX 4 months after the Intraorbital dose RTX
Case 3 [5]	41 years old woman   Hashimoto’s thyroiditis on  levothyroxine   One-year history of pain in the superotemporal left orbit   Visual acuity 0.2 logMaR in the left eye and 0.0 logMaR in the right eye   Left ocular globe medially displaced by a palpable mass under the superotemporal orbital rim   Upper eyelid erythema and edema, and ptosis and pain on left eye movements	1.0–1.5 mg/kg of prednisone per day for 1 week and taper   Intraorbital RTX at a dose of 10 mg once a week for 4 weeks
Case 4 [6]	56 years old woman   Hemochromatosis   Painful, red, and swollen right eye   Visual acuity 6/9 on the right, 6/6 on the left.   Radiation of the pain to the right hemifacial and intracranial area   Proptosis, excessive tearing, painful and restricted eye movements   Intraocular pressure mildly elevated	Oral prednisolone for 12 months   Azathioprine 100–150 mg and cyclosporin 100–300 mg) failed to produce meaningful results   Methotrexate 10 mg weekly   Targeted low-dose radiation therapy   RTX 1000 mg intravenous infusion administered on day 1 and day 15, repeated every 6 months over a period of 3 years
Case 5 [7]	43 years old woman   17-Year history of seropositive rheumatoid arthritis 4-month history of diplopia   Visual acuity 0.6 right eye and 0.0 left eye, best corrected on logMAR.   Right-side proptosis, ptosis and diplopia on lateral gaze   Restriction of movement in the right eye and reduction in vision   Mild right-side proptosis and persistent choroidal folds affecting the right macula	Rheumatoid arthritis was very well controlled on  adalimumab   3 pulses of IV methylprednisolone 250 mg   Methotrexate 5 mg/week and folic acid 5 mg 3 days/week   One cycle of RTX infusionsadministered 2 weeks apart