Figure 2.

ERα Genomic Signaling Is Preserved in ERα^KI/KITie2^Cre+ Mice

(A) Representative uterine morphologies of ERα^KI/KITie2^Cre mice after ovariectomy (OVX) and OVX+E2 supplementation. (B) ERα^KI/KITie2^Cre mice uterine weights (ERα^KI/KITie2^Cre−, n = 7-8; ERα^KI/KITie2^Cre+, n = 8). (C) Fertility analysis of ERα^KI/KITie2^Cre female mice. Litter sizes are shown as the number of pups per litter. (D) Endothelial estrogen response element–containing gene expressions by E2 stimulation. Data in B and D were analyzed by 2-way analysis of variance for “genotype × estrogen status” interaction. Data in C were analyzed by the unpaired Student's t-test. ∗P < 0.05. Data are presented as mean ± SEM. Abbreviations as in Figure 1.