EDEN Electrogram Morphology to Guide Intramyocardial Guidewire Navigation
Depth is shown in millimeters from the epicardial surface. The injury current (ST-segment elevation subsuming the QRS complex) exhibits a biphasic pattern during wire advancement from the epicardial toward the endocardial surface, gradually increasing to a maximum in the midmyocardium. The ST-segment elevation then declines with additional advancement toward the endocardium. The injury current disappears when the guidewire tip enters the left ventricular chamber at 16-mm. Color-coded regions indicate how operators interpret electrocardiographic radial depth navigation (EDEN) electrograms during navigation: deep myocardial (green), subendocardial and subepicardial (orange), and intracavity (red).