Table 2.
Structure and Function Measurements Before and After MIRTH in Healthy Animals
| Before (n = 11) | After (n = 11) | Day 90a (n = 7) | ||
|---|---|---|---|---|
| LVEDVI, mL/m2 | Combined | 108.2 (104.2-114.8) | 95.5 (93.7-104.5)b | 111.6 (104.5-124.8) |
| Mid | 106.1 (99.9-111.1) | 93.9 (90.7-97.7) | 111.6 (106.8-114.8) | |
| Basal | 119.6 (107.3-129.7) | 103.2 (97.3-110.9) | 135.3 (118.8-151.8) | |
| LVESVI, mL/m2 | Combined | 57.5 (53.4-62.3) | 48.1 (44.8-53.5)c | 54.4 (44.6-65.3) |
| Mid | 56.0 (53.4-58.3) | 45.1 (43.2-49.2)d | 54.4 (47.3-63.8) | |
| Basal | 65.4 (57.9-70.3) | 51.4 (48.3-56.0) | 70.3 (56.1-84.5) | |
| LVEF, % | Combined | 47 (45-48.5) | 50 (49.5-53.0)d | 52 (46-59) |
| Mid | 47 (45-47.5) | 51 (48-55) | 52 (50-58) | |
| Basal | 47 (44.3-50.3) | 50 (50-50) | 50 (46-55) | |
| GLS, % | Combined | −11.4 (−12.2 to −10.1) | −11.5 (−12.7 to −9.5) | −8.9 (−10.2 to −7.8)d |
| Mid | −10.6 (−11.8 to −9.3) | −9.7 (−11.7 to −8.3) | −9.0 (−9.7 to −8.2) | |
| Basal | −11.7 (−12.3 to −11.5) | −13.5 (−14.8 to −12.2) | −10.9 (−11.8 to −9.9) | |
| GRS, % | Combined | 50.3 (42.2-58.6) | 52.6 (50.6-60.7) | 50.5 (44.1-56.3) |
| Mid | 46.0 (37.9-58.6) | 51 (47.2-55.2) | 44.1 (39.6-48.0) | |
| Basal | 52.9 (49.5-57.1) | 60.4 (54.9-66.2) | 57.3 (56.7-57.8) | |
| LVEDP, mm Hg | Combined | 12 (10-14) | 15 (11-16)d | 10 (8-12) |
| Mid | 12 (10-14) | 16 (12-18) | 11 (10-12) | |
| Basal | 12 (10-12) | 14 (11-15) | 9 (9-10) |
Values are median (quartile 1-quartile 3).
GLS = global longitudinal strain; GRS = global longitudinal strain; LVEDP = left ventricular end-diastolic pressure; LVEDVI = indexed left ventricular end-diastolic volume; LVEF = left ventricular ejection fraction; LVESVI = indexed left ventricular end systolic volume; MIRTH = Myocardial Intramural Remodeling by Transvenous TeTHer.
a
Excluding separated implants.
b
P < 0.01,
c
P < 0.001, and
d
P < 0.05 following comparison to baseline value using the Wilcoxon signed rank test. Values highlighted in bold are statistically significant.