Table 3.
Myocardial Energetics (Pressure-Volume Loop Measurements)
| Cohort | Shortening (%) | EDV (mL | ESV (mL) | Ees (mm Hg/mL) | EDPVR Slope (mm Hg/mL) | SV (mL) | V0 (mL) | Stroke Work (mm Hg/mL) | Potential Energy (mm Hg/mL) | PVA (mm Hg/mL) | Ventricular Mechanical Efficiency (%) | PRSW (mm Hg) |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| ICM (n = 5) | 0 | 277 (215-325) | 198 (140-258) | 0.80 (0.32-1.06) | 0.006 (0.002-0.015) | 73 (67-77) | 73 (13-97) | 4,600 (3,536-4,674) | 3,255 (1,574-7,380) | 7,984 (4,813-11,989) | 59 (39-67) | 30.2 (6.39-47.9) |
| 9 (7-14) | 315 (197-319) | 251 (125-252) | 0.38 (0.36-0.93) | 0.009 (0.009-0.010) | 69 (67-69) | 70 (67-77) | 4,196 (3,054-4,413) | 5,915 (1,412-6,284) | 10,094 (4,466-10,697) | 42 (41-68) | 36.6 (35.0-49.0) | |
| 18a(17-20) | 277 (226-314) | 197 (170-245) | 1.01 (0.86-1.24) | 0.010 (0.006-0.022) | 69 (64-76) | 115 (85-130) | 4,013 (2,836-4,446) | 1,892 (1,499-2,828) | 5,954 (4,606-7,185) | 68 (61-71) | 56.5 (48.0-64.6) | |
| 33 (26-35) | 250 (179-270) | 186 (126-192) | 0.66 (0.47-0.79) | 0.027 (0.014-0.039) | 55 (50-65) | 54 (29-87) | 3,128 (1,924-3,543) | 3,199 (1,992-3,807) | 6,472 (3,746-7,160) | 51 (41-55) | 30.1 (4.2-47.0) | |
| 49 (42-51) | 243 (226-293) | 198 (171-200) | 0.35 (0.25-0.45) | 0.044 (0.029-0.060) | 52 (40-66) | −30 (−50 to 50) | 2,630 (2,247-4,033) | 3,660 (2,180-6,070) | 6,957 (5,727-9,246) | 37 (26-55) | 13.8 (−11.0 to 28.8) | |
| Healthy (n = 3) | 0 | 109 (106-113) | 64 (51-71) | 0.93 (0.83-1.28) | 0.003 (0.002-0.004) | 46 (45-54) | −1 (−25 to 19) | 2,745 (2,358-3,418) | 1,972 (1,766-2,637) | 4,511 (4,330-6,087) | 56 (54-61) | 45.6 (43.3-51.2) |
| 10.5 (10-12) | 104 (102-109) | 60 (53-71) | 1.09 (0.97-1.26) | 0.006 (0.005-0.006) | 42 (39-48) | 4 (−14 to 15) | 2,553 (2,117-3,047) | 1,801 (1,521-2,514) | 4,268 (3,719-5,341) | 57 (55-58) | 36.7 (33.6-39.6) | |
| 21 (20-24) | 96 (94-99) | 58 (49-68) | 0.97 (0.71-1.18) | 0.008 (0.006-0.008) | 37 (31-43) | −10 (−26 to −1) | 1,888 (1,776-2,325) | 2,265 (1,701-2,637) | 4,336 (4,026-5,069) | 51 (40-58) | 32.0 (24.3-37.7) | |
| 33.5 (31.5-35) | 93 (90-94) | 63 (56-70) | 0.37 (0.27-0.93) | 0.010 (0.007- 0.018) | 26 (23-31) | −83 (−133 to −2) | 1,342 (1,214-1,862) | 4,761 (2,541-6,993) | 5,967 (5,073-8,254) | 22 (16-52) | 18.2 (13.3-25.5) | |
| 47 (42-47) | 81 (79-87) | 51 (50-58) | 0.66 (0.33-0.92) | 0.008 (0.006- 0.015) | 30 (20-37) | −42 (−75 to −25) | 1,662 (636-2,495) | 2,847 (2,572-3,709) | 4,509 (4,389-4,521) | 37 (13-49) | 24.9 (21.0-38.6) |
Values are median (quartile 1-quartile 3).
EDV = end-diastolic volume; EDPVR = end-diastolic pressure volume relationship; Ees = end-systolic elastance; ESV = end-systolic volume; ICM = ischemic cardiomyopathy; MIRTH = Myocardial Intramural Remodeling by Transvenous Tether; PRSW = preload-recruitable stroke work; PVA = pressure-volume area; SV = stroke volume.
a
Optimum MIRTH shortening. Values in bold correspond to optimum MIRTH shortening.