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. 2023 Jan 2;7(2):264–278. doi: 10.1038/s41559-022-01925-6

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© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Extended Data Fig. 9 — a, Immunofluorescence staining of TBR1 (red) and CTIP2 (green) in Hoechst-stained (blue) cortical organoids grown for 60 days from wild type hESCs (CTRL), hESCs with ENSG00000205704-KO (KO), and hESCs with the over expression of ENSG00000205704 (OE). Scale bars, 100 μm. b, Quantifications of the immunofluorescence staining for TBR1 in CTRL, KO and OE; n = 3 biologically independent organoids; data are presented as mean values + /- SEM; one-way ANOVA, P value = 1.8e-4; Dunnett’s multiple comparisons test, KO vs CTRL P value = 2.4e-4, OE vs CTRL P value = 9.7e-1. c, Quantifications of the immunofluorescence staining for CTIP2 in CTRL, KO and OE; n = 3 biologically independent organoids; data are presented as mean values + /- SEM. One-way ANOVA, P value = 6.2e-4; Dunnett’s multiple comparisons test, KO vs CTRL P value = 5.8e-3, OE vs CTRL P value = 3.1e-2. ***P value ≤ 0.001.