Table 1.
Temporal alteration of inflammatory meiators in asphyxiated neonates.
| UB | 1–6 h | ∼24 h | 24 h∼ | References |
|---|---|---|---|---|
| Increase | ||||
| IL-6 | IL-6 | IL-6 | IL-6 | (18–20, 127–130) |
| IL-8 | IL-8 | IL-8 | (17, 18, 127) | |
| TNF-α | TNF-α | TNF-α | (19, 128, 131) | |
| IL-1β | IL-1β | (19) | ||
| IL-10 | IL-10 | (18) | ||
| IL-16 | (129, 132, 133) | |||
| S100B | S100B | S100B | S100B | (128, 135) |
| GFAP | GFAP | GFAP | (127, 36) | |
| HMGB1 | HMGB1 | (21, 131) | ||
| VEGF | VEGF | (127, 137) | ||
| LOX-1 | (31) | |||
| GM-CSF | (17) | |||
| NO | (6) | |||
| Decrease | ||||
| VEGF | VEGF | (29) | ||
| IL-6 | (20) | |||
| TNF-α | (130) | |||
BDNF, brain-derived neurotrophic factor; GFAP, glial fibrillary acidic protein; GM-CSF, granulocyte-macrophage colony stimulating factor; HMGB1, high- mobility group box 1; IGF-1, insulin-like growth factor 1; IL, interleukin; LOX-1, lectin-like oxidized low-density lipoprotein receptor-1; NO, nitric oxide; TNF-α, tumor necrosis factor-α; UB, umbilical cord blood; VEGF, vascular endothelial growth factor.