Table 2.

Temporary changes in inflammatory mediators in asphyxiated neonates treated with therapeutic hypothermia.

1–6 h	∼24 h	24 h∼	References
Increase
VEGF	VEGF	VEGF	(138, 139)
	GFAP	GFAP	(117, 138)
	G-CSF	GM-CSF	(30, 76)
		RANTES	(138)
Decrease
IL-6		IL-6	(139)
	VEGF		(30, 117)
		IL-8	(140)
		IL-1RA, IL-10	(141)
		S100B	(134)
		RANTES	(76)

G-CSF, granulocyte colony stimulating factor; GFAP, glial fibrillary acidic protein; GM-CSF, granulocyte-macrophage colony stimulating factor; IL, interleukin; IL-1RA, Interleukin-1 receptor antagonist; RANTES, regulated upon activation, normal T cell expressed and secreted; VEGF, vascular endothelial growth factor.