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. 2023 Jan 27;14:1089809. doi: 10.3389/fimmu.2023.1089809

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Copyright © 2023 Wang, Zhang, Yang, Li, Li, Zhang, Long, Lu, Liu, Yang, Liu, Hong, Wu and Ma

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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MiR-222-3p inhibitor plays CAC-suppressive roles in vivo. (A) qRT-PCR analysis of miR-222-3p in the IECs from AOM/DSS-induced mice. (B) Macroscopic images of tumors in the intestines of AOM/DSS-induced mice. (C) Images of AOM/DSS-induced mice. (D, E) Intestinal tumor numbers and tumor volumes were recorded. (F–I) morphological observation with H&E-stained colon sections as indicated. (J–M) Immunohistochemical analyses of BRG1 expression in colon tissues, and arrows indicate IECs locations. Data are presented as the median (P25, P75) (n = 8) in (D, E) and mean ± SD in (A) (n = 8). ^* P < 0.05, ^*** P < 0.001. Normal control: Normal control group; CAC: CAC group; AAV-NC: CAC+ AAV-negative control group; AAV-222-3p inhibitor: CAC+ miR-222-3p inhibitor group. Scale bar: 100 µm. N.S., no significance.