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. 2023 Feb 9;14:709. doi: 10.1038/s41467-023-36148-1

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© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 7 — EVs isolated from the stromal vascular fraction (SVF) and adipocyte fraction of liposuction samples from 11 self-reported female human subjects were analyzed by LC-MS/MS a PCA space differences and b Volcano plot displaying the significantly enriched expression of proteins involved in GPCR and calcium signaling, vesicle docking and insulin secretion in human adipocyte EVs (hAdEVs) compared to their expression in human SVF EVs. Significance was determined by two-samples t-test with 0.1 FDR.