Figure 6.

Cartoon summarizing key findings of this study. In 15-month-old App^NL-F/NL-F mice, the presence or absence of Sst has no effect on whole-brain steady-state neprilysin transcript, protein, or activity levels (1). Instead, Sst slows the formation of Aβ oligomers that can be visualized as 55–150 kDa SDS-resistant 82E1-reactive bands (2) and shifts Aβ amyloid formation and deposition (3). No effect of Sst was observed on steady-state tau protein levels or the tau phosphorylation at key AD phospho-acceptor sites. This cartoon was generated with Adobe Illustrator (version 5.9.0.372; https://www.adobe.com/). A similar cartoon was originally created and published under CC BY 4. 0 open access license by a subset of the authors (see Fig. 2 in¹²). Because these authors had retained copyright, no permission were needed for them to make the adjustments to the cartoon implemented here.