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. 2023 Jan 27;14:1018867. doi: 10.3389/fimmu.2023.1018867

Table 8.

Effects of feeding medium-chain fatty acid on blood bile acid metabolism of early lactation cows2.

Variable3 (μ mol/L) Treatment1 SEM P-value
CON MCFA Treatment Time Treatment ×Time
LCA 0.02 0.02 0.002 0.37 <0.01 <0.01
UDCA 0.017 0.015 0.002 0.50 0.04 0.06
HDCA 0.03a 0.02b 0.002 0.02 0.02 <0.01
CDCA 0.30 0.61 0.118 0.13 0.03 0.03
DCA 1.20 3.47 0.592 0.15 0.05 0.11
HCA 0.05a 0.01b 0.006 <0.01 <0.01 <0.01
CA 18.77 21.04 3.547 0.71 <0.01 0.27
GLCA 0.08 0.08 0.012 0.81 0.11 0.79
GCDCA 0.82 0.71 0.153 0.70 <0.01 0.33
GDCA 2.03 1.90 0.290 0.80 0.01 0.66
GCA 9.30 6.86 1.328 0.28 <0.01 0.29
TCDCA 0.45 0.43 0.096 0.89 0.10 0.13
TCA 5.02 2.74 0.718 0.08 0.08 0.03
TBA 39.98 38.70 5.626 0.89 <0.01 0.76
CA/CDCA 75.35 89.10 20.696 0.75 0.16 0.85

SEM, standard error of mean.

a-bMeans within a row with unlike superscripts differ (P ≤ 0.05).

1CON, control treatment, basic diet with no medium chain fatty acids, n = 9. MCFA, MCFA treatment, basic diet and medium chain fatty acids 20 g/d, n = 9.

2Early lactation, from 1 d to 28 d after calving.

3LCA, lithocholic acid; UDCA, ursodeoxycholic acid; HDCA, hyodeoxycholic acid; CDCA, chenodeoxycholic acid; DCA, deoxycholic acid; HCA, hyocholic acid; CA, cholic acid; GLCA, cholic acid; GCDCA, glycochenodeoxycholic acid; GDCA, glycodeoxycholic acid; GCA, glycocholic acid; TCDCA, taurochenodeoxycholic acid; TCA, taurocholic acid; TBA, total bile acid.