Table 2.

Expression of ELAVL4 and ELAVL4 targets after ELAVL4 manipulation

	ELAVL4 knock out						ELAVL4 overexpression				ELAVL4 rescue in knock out
	RNAseq				Protein		RNAseq				RNAseq				Protein
	fAD corrected		fAD		fAD corrected		fAD		fAD corrected		fAD		fAD corrected		fAD
Gene	FC	FDR-P	FC	FDR-P	FC	FDR-P	FC	FDR-P	FC	FDR-P	FC	FDR-P	FC	FDR-P	FC	FDR-P
ELAVL4/HuD	−4,47	2,86E-37	3,24	8,13E-34	N.A.	N.D.	2,86	8,49E-33	2,62	2,25E-31	15,14	3,11E-48	9,40	1,13E-45	1,635	1,21E-11
CAMK2A	1,92	8,26E-12	1,10	2,42E-01	N.A.	N.D.	−1,26	5,71E-02	−1,29	3,13E-02	−1,96	1,30E-10	−1,53	1,43E-05	N.A	N.D.
BDNF	1,17	4,83E-03	−1,19	1,55E-01	N.A.	N.D.	−1,13	1,89E-01	−1,04	7,80E-01	−1,18	1,13E-02	−1,15	3,58E-02	N.A	N.D.
GAP43	−1,07	4,00E-03	1,11	1,19E-04	1,21	1,05E-03	1,09	1,17E-02	1,12	1,07E-03	1,14	9,46E-06	1,07	3,02E-02	−1,19	1,89E-03
APP	1,16	7,03E-13	−1,06	4,32E-04	N.A.	N.D.	1,02	4,51E-01	−1,10	8,38E-02	−1,05	4,18E-03	−1,03	1,16E-01	N.A	N.D.
BACE1	1,13	6,71E-04	1,03	4,78E-01	N.A.	N.D.	1,08	1,26E-01	−1,05	8,54E-01	1,01	8,06E-01	1,02	6,84E-01	N.A	N.D.
ADAM10	−1,10	1,69E-03	−1,02	6,53E-01	N.A.	N.D.	−1,10	2,73E-02	−1,04	4,74E-01	−1,22	5,78E-07	−1,12	3,48E-03	N.A	N.D.
NEP	−3,21	7,98E-08	−1,23	3,39E-01	N.A.	N.D.	−1,35	2,77E-01	−1,14	7,80E-01	−1,07	8,49E-01	−1,26	4,01E-01	N.A	N.D.
SERPINI1	1,29	3,55E-13	1,01	7,54E-01	N.A.	N.D.	−1,04	4,02E-01	−1,06	2,30E-01	−1,01	7,64E-01	−1,07	4,68E-02	N.A	N.D.
TAU	−1,02	5,66E-01	−1,02	4,84E-01	1,09	6,02E-01	1,15	1,48E-04	1,38	6,24E-01	1,16	2,85E-06	1,11	4,07E-04	1,08	5,07E-01
ACHE	1,02	6,09E-01	−1,10	5,86E-03	N.A.	N.D.	1,18	2,15E-04	1,18	1,26E-04	1,30	1,63E-09	1,20	3,80E-06	N.A	N.D.

Abbreviations: FC, Fold change; FDR-P, FDR corrected P-value