Table 2. Summary of Clinical Data and ORN Characteristics Following PRT.

Patient No.	ORN				Calculated radiation dose to ORN site, GyRBE		Etiology	Time to ORN, mo	Management of ORN	Follow-up, mo	Outcome at last follow-up
	Laterality	Location	Clinical presentation	Grade at initial diagnosis	Mean	Maximum
1	I/L	Maxillary anterior	Avulsed tooth	1	76.5	81.2	Spontaneous	41	CHX	36	Complete resolution
2	I/L	Mandibular posterior	Pain, EBA (3 × 1 cm)	2	60.9	66.2	Spontaneous	2	CHX, ABX	25	Progression
3	I/L	Mandibular posterior	Pain, purulent discharge EBA (1 × 1 cm)	2	57.1	69.3	Spontaneous	42	CHX, ABX, PENT-E	32	Progression
4	I/L	Mandibular ramus	Asymptomatic	0	68.1	69.4	Spontaneous	24	CHX	31	Stable
5	I/L	Mandibular posterior	Pain, purulent discharge	2	57.6	66.2	Spontaneous	7	CHX, ABX	42	Progression
6	C/L	Maxillary posterior	Draining fistula	3	73.9	79.0	Spontaneous	35	CHX, ABX, surgical resection + graft	35	Complete resolution
7	I/L	Mandibular posterior	Pain, tooth mobility, EBA (1.5 × 1 cm)	2	52.5	72.9	Spontaneous	6	CHX, ABX, debridement, PENT-E	35	Complete resolution
8	I/L	Mandibular posterior	Pain, EBA (2 × 2 cm)	2	45.1	73.6	Spontaneous	6	CHX, ABX, PENT-E, HBOT	58	Progression
9	I/L	Mandibular posterior	EBA (0.8 × 1 cm)	1	57.1	71.3	Spontaneous	40	CHX, PENT-E	36	Stable
10	I/L	Mandibular posterior	Pain, swelling, purulent discharge	2	62.7	69.8	Spontaneous	45	CHX, ABX, PENT-E	0	Stable
11	I/L	Mandibular posterior	Swelling	2	64.8	68.5	Spontaneous	17	CHX, ABX, PENT-E	16	Stable
12	I/L	Maxillary posterior	3 EBAs (0.3 × 0.3 cm, 0.2 × 0.3 cm, 0.1 × 0.5 cm)	1	45.5	61.8	Spontaneous	83	CHX, PENT-E	11	Stable
13	I/L	Mandibular posterior	Pain, tooth mobility	2	66.6	69.1	Spontaneous	74	CHX, ABX	7	Stable

Abbreviations: ABX, antibiotics; CHX, chlorhexidine; C/L, contralateral; EBA, exposed bone area; GyRBE, gray relative biological effectiveness; HBOT, hyperbaric oxygen therapy; I/L, ipsilateral; ORN, osteoradionecrosis; PENT-E, pentoxifylline–vitamin E.