Table 3.
Identified metabolites discriminating the hypo group from the hyper and control groups.
| Identifier | Metabolite | Chain Length * | Mean m/z | Exact m/z | Δ ppm | Hypo/Control | Hypo/Hyper | ||
|---|---|---|---|---|---|---|---|---|---|
| % | p-Value ** | % | p-Value ** | ||||||
| Direct Parent: Acylcarnitines | |||||||||
| M230T152 | Butenylcarnitine | C4:1 | 230.139 | 230.1387 | 1.3 | 0.77 | 0.381 | 0.07 | 0.003 |
| M248T124 | Hydroxybutyrylcarnitine | C4-OH | 248.149 | 248.1492 | −0.8 | 0.34 | 0.151 | 0.08 | 0.014 |
| M244T198 | Tiglylcarnitine | C5:1M | 244.154 | 244.1543 | −1.2 | 0.63 | 0.065 | 0.31 | 0.004 |
| M275T335 | Heptanoylcarnitine | C7 | 274.200 | 274.2013 | −4.7 | 0.63 | 0.116 | 0.55 | 0.062 |
| M305T224 | Hydroxyoctanoyl carnitine | C8-OH | 304.211 | 304.2118 | −2.6 | 0.79 | 0.394 | 0.21 | 0.005 |
| M344T572 | Dodecanoylcarnitine | C12 | 344.279 | 344.2795 | −1.5 | 0.32 | 0.053 | 0.34 | 0.024 |
| M360T500 | Hydroxydodecanoyl carnitine | C12-OH | 360.274 | 360.2744 | −1.1 | 0.62 | 0.158 | 0.35 | 0.015 |
| M388T570 | Hydroxytetradecanoylcarnitine | C14-OH | 388.305 | 388.3057 | −1.8 | 0.69 | 0.152 | 0.38 | 0.003 |
| M386T556 | Hydroxytetradecenoylcarnitine | C14:1-OH | 386.290 | 386.2901 | −0.3 | 0.73 | 0.345 | 0.27 | 0.010 |
| M416T608 | Hydroxyhexadecanoylcarnitine | C16-OH | 416.337 | 416.3371 | −0.2 | 0.62 | 0.122 | 0.46 | 0.022 |
| M414T587 | Hydroxyhexadecenoylcarnitine | C16:1-OH | 414.321 | 414.3214 | −1.0 | 0.46 | 0.169 | 0.34 | 0.003 |
| M412T567 | Hydroxyhexadecadienoylcarnitine | C16:2-OH | 412.305 | 412.3057 | −1.7 | 0.63 | 0.119 | 0.47 | 0.005 |
| M442T619 | Hydroxyoctadecenoylcarnitine | C18:1-OH | 442.353 | 442.3527 | 0.7 | 0.69 | 0.280 | 0.42 | 0.022 |
| Other | |||||||||
| M166T126 | 7-Methylguanine | 166.073 | 166.0723 | 4.2 | 1.64 | 0.142 | 2.13 | 0.022 | |
| M283T132 | 1-Methylinosine | 283.103 | 283.1037 | −2.5 | 1.67 | 0.175 | 1.78 | 0.089 | |
| M303T133 | Histidylphenylalanine | 303.145 | 303.1452 | −0.7 | 0.73 | 0.545 | 0.25 | 0.092 | |
| M209T138 | 5-Hydroxyindoleacetic acid | 192.066 | 192.0655 | 2.6 | 0.64 | 0.142 | 0.52 | 0.121 | |
| M234T374 | 3,5-Dihydroxyphenylvaleric acid | 211.096 | 211.0965 | −2.4 | 1.05 | 0.831 | 1.92 | 0.004 | |
| M382T599 | Sphinganine 1-phosphate | 382.273 | 382.2717 | 3.4 | 1.34 | 0.211 | 1.63 | 0.036 | |
| M302T620 | Sphinganine | 302.305 | 302.3054 | −1.3 | 1.60 | 0.223 | 1.85 | 0.081 | |
* Number of carbons, saturations, and alcohols on the ester group of acylcarnitines; ** FDR-adjusted p-values, bold values highlight significant results p < 0.05. Identified metabolites were matched according to m/z to the HMDB and/or METLIN public databases, and as such, constitute level 2 or 3 putative metabolite identification according to the MSI guidelines [20].