Table 1.
Demographic, tumor, and treatment data for breast cancer patients (diagnosed 2010–2014) in the NCDB and SEER. NCDB: National Cancer Database. SEER: Surveillance, Epidemiology, End Results Program. NOS: not otherwise specified. ER: estrogen receptor. PR: progesterone receptor. HER2: human-epidermal-growth-factor-receptor-2.
| NCDB n=775,996 | SEER n=263,016 | |||||||
|---|---|---|---|---|---|---|---|---|
| Complete | Missing Data | Complete | Missing Data | |||||
| N | % | N | % | N | % | N | % | |
| Sex | ||||||||
| Female | 549860 | 99.1 | 218877 | 98.9 | 226598 | 99.3 | 34437 | 99.2 |
| Male | 4836 | 0.9 | 2423 | 1.1 | 1696 | 0.7 | 285 | 0.8 |
| Age (years) | ||||||||
| <40 | 27376 | 4.9 | 9876 | 4.5 | 11091 | 4.9 | 1569 | 4.5 |
| 40–70 | 367911 | 66.3 | 143679 | 64.9 | 150847 | 66.1 | 21370 | 61.5 |
| >70 | 140941 | 25.4 | 60471 | 27.3 | 58783 | 25.7 | 10709 | 30.8 |
| missing | 18468 | 3.3 | 7274 | 3.3 | 7573 | 3.3 | 1074 | 3.1 |
| Race | ||||||||
| White | 466936 | 84.2 | 176560 | 79.8 | 181692 | 79.6 | 26169 | 75.4 |
| Black | 64022 | 11.5 | 26806 | 12.1 | 25256 | 11.1 | 4327 | 12.5 |
| Other | 23738 | 4.3 | 10813 | 4.9 | 21346 | 9.4 | 3091 | 8.9 |
| Unknown | 0 | 0 | 7121 | 3.2 | 0 | 0 | 1135 | 3.3 |
| Spanish/Hispanic Origin | ||||||||
| Hispanic | 27857 | 5.0 | 14176 | 6.4 | 24285 | 10.6 | 4141 | 11.9 |
| Not Hispanic | 526839 | 95.0 | 178351 | 80.6 | 204009 | 89.4 | 30581 | 88.1 |
| Unknown | 0 | 0 | 28773 | 13.0 | 0 | 0 | 0 | 0 |
| Insurance | ||||||||
| Private Insurance/Managed Care | 285577 | 51.5 | 102232 | 46.2 | ||||
| Insured | 167666 | 73.4 | 18898 | 54.4 | ||||
| Insured/No specifics | 30229 | 13.2 | 4754 | 13.7 | ||||
| Any Medicaid | 26551 | 11.6 | 4000 | 11.5 | ||||
| Medicare | 213912 | 38.6 | 82617 | 37.3 | ||||
| Medicaid | 37553 | 6.8 | 14788 | 6.7 | ||||
| Not Insured | 11867 | 2.1 | 5376 | 2.4 | 3848 | 1.7 | 814 | 2.3 |
| Other Government | 5787 | 1.0 | 2150 | 1.0 | ||||
| Insurance Status Unknown | 0 | 0 | 14137 | 6.4 | 0 | 0 | 6256 | 18.0 |
| Percent of area of residence with less than high school diploma | ||||||||
| >=21.0% | 78887 | 14.2 | 37317 | 16.9 | 46284 | 20.3 | 7218 | 20.8 |
| 13.0–20.9% | 131697 | 23.7 | 53373 | 24.1 | 70507 | 30.9 | 11792 | 34.0 |
| 7.0–12.9% | 185307 | 33.4 | 70137 | 31.7 | 94912 | 41.6 | 13337 | 38.4 |
| <7.0% | 158805 | 28.6 | 58647 | 26.5 | 16591 | 7.3 | 2310 | 6.7 |
| missing | 0 | 0 | 1826 | 0.8 | 0 | 0 | 65 | 0.2 |
| Median household income | ||||||||
| >=$63,000 | 205624 | 37.1 | 80075 | 36.2 | 89059 | 39.0 | 12375 | 35.6 |
| $48,000-$62,999 | 149812 | 27.0 | 57065 | 25.8 | 95490 | 41.8 | 15628 | 45.0 |
| $38,000-$47,999 | 118043 | 21.3 | 46573 | 21.0 | 31434 | 13.8 | 4640 | 13.4 |
| < $38,000 | 81217 | 14.6 | 35470 | 16.0 | 12311 | 5.4 | 2014 | 5.8 |
| missing | 0 | 0 | 2117 | 1.0 | 0 | 0 | 65 | 0.2 |
| Grade | ||||||||
| Well differentiated, differentiated, NOS | 124217 | 22.4 | 37609 | 17.0 | 51061 | 22.4 | 4631 | 13.3 |
| Moderately differentiated, moderately well differentiated, intermediate differentiation | 242518 | 43.7 | 72278 | 32.7 | 99126 | 43.4 | 8858 | 25.5 |
| Poorly differentiated | 186653 | 33.6 | 52008 | 23.5 | 77417 | 33.9 | 6729 | 19.4 |
| Undifferentiated, anaplastic | 1308 | 0.2 | 460 | 0.2 | 690 | 0.3 | 217 | 0.6 |
| Cell type not determined, not stated or not applicable, unknown primaries, high grade dysplasia | 0 | 0 | 58945 | 26.6 | 0 | 0 | 14287 | 41.1 |
| ER status | ||||||||
| Positive/elevated | 451488 | 81.4 | 171621 | 77.6 | 188273 | 82.5 | 22334 | 64.3 |
| Negative/normal | 102961 | 18.6 | 38462 | 17.4 | 39914 | 17.5 | 5252 | 15.1 |
| Borderline, undetermined whether positive or negative | 247 | 0.0 | 113 | 0.1 | 107 | 0.0 | 30 | 0.1 |
| Missing/Unknown | 0 | 0 | 11104 | 5.0 | 0 | 0 | 7106 | 20.5 |
| PR status | ||||||||
| Positive/elevated | 396889 | 71.6 | 148844 | 67.3 | 163842 | 71.8 | 18246 | 52.5 |
| Negative/normal | 157167 | 28.3 | 59785 | 27.0 | 64160 | 28.1 | 8448 | 24.3 |
| Borderline, undetermined whether positive or negative | 640 | 0.1 | 326 | 0.1 | 292 | 0.1 | 64 | 0.2 |
| Missing/Unknown | 0 | 0 | 12345 | 5.6 | 0 | 0 | 7964 | 22.9 |
| HER2 status | ||||||||
| Positive/elevated | 80224 | 14.5 | 28205 | 12.7 | 33729 | 14.8 | 4056 | 11.7 |
| Negative/normal | 459108 | 82.8 | 153574 | 69.4 | 189584 | 83.0 | 17341 | 49.9 |
| Borderline, undetermined whether positive or negative | 11913 | 2.1 | 5132 | 2.3 | 4981 | 2.2 | 757 | 2.2 |
| Not applicable and not collected | 3451 | 0.6 | 1038 | 0.5 | - | - | - | - |
| Missing/Unknown | 0 | 0 | 33351 | 15.1 | 0 | 0 | 12568 | 36.2 |
| T stage | ||||||||
| 0 | 12461 | 2.2 | 6896 | 3.1 | 83 | < 0.1 | 254 | 0.7 |
| 1 | 342490 | 61.7 | 86833 | 39.2 | 136474 | 59.8 | 15275 | 44.0 |
| 2 | 149295 | 26.9 | 38060 | 17.2 | 69447 | 30.4 | 6658 | 19.2 |
| 3 | 28631 | 5.2 | 8612 | 3.9 | 13468 | 5.9 | 1778 | 5.1 |
| 4 | 21819 | 3.9 | 8743 | 4.0 | 8822 | 3.9 | 2252 | 6.5 |
| missing | 0 | 0 | 72156 | 32.6 | 0 | 0 | 8505 | 24.5 |
| N stage | ||||||||
| 0 | 452476 | 81.6 | 127369 | 57.6 | 156198 | 68.4 | 20365 | 58.7 |
| 1 | 78820 | 14.2 | 23031 | 10.4 | 52389 | 22.9 | 6806 | 19.6 |
| 2 | 14316 | 2.6 | 4519 | 2.0 | 12193 | 5.3 | 1272 | 3.7 |
| 3 | 9084 | 1.6 | 3280 | 1.5 | 7514 | 3.3 | 980 | 2.8 |
| missing | 0 | 0 | 63101 | 28.5 | 0 | 0 | 5299 | 15.3 |
| M stage | ||||||||
| 0 | 533397 | 96.2 | 161905 | 73.2 | 219386 | 96.1 | 30399 | 87.5 |
| 1 | 21299 | 3.8 | 13529 | 6.1 | 8908 | 3.9 | 4306 | 12.4 |
| missing | 0 | 0 | 45866 | 20.7 | 0 | 0 | 17 | 0.0 |
| Surgical Treatment | ||||||||
| Lumpectomy | 295114 | 53.2 | 101053 | 45.7 | 119913 | 52.5 | 12483 | 36.0 |
| Mastectomy | 228460 | 41.2 | 89480 | 40.4 | 95258 | 41.7 | 11359 | 32.7 |
| No surgery | 30843 | 5.6 | 28757 | 13.0 | 12945 | 5.7 | 9972 | 28.7 |
| Unknown type of surgery | 279 | 0.1 | 429 | 0.2 | 131 | 0.1 | 153 | 0.4 |
| Missing | 0 | 0 | 1581 | 0.7 | 47 | 0.0 | 755 | 2.2 |
| Chemotherapy | ||||||||
| Yes | 247427 | 44.6 | 81006 | 36.6 | - | - | - | - |
| No | 307269 | 55.4 | 120512 | 54.5 | - | - | - | - |
| Unknown/Missing | 0 | 0 | 19782 | 8.9 | - | - | - | - |
| Radiation | ||||||||
| Yes | 326567 | 58.9 | 107341 | 48.5 | - | - | - | - |
| No | 228129 | 41.1 | 108392 | 49.0 | - | - | - | - |
| Unknown/Missing | 0 | 0 | 5567 | 2.5 | - | - | - | - |
| Charlson-Deyo Score | ||||||||
| 0 | 456545 | 82.3 | 186820 | 84.4 | - | - | - | - |
| 1 | 78034 | 14.1 | 27231 | 12.3 | - | - | - | - |
| 2 | 15387 | 2.8 | 5466 | 2.5 | - | - | - | - |
| >=3 | 4730 | 0.9 | 1783 | 0.8 | - | - | - | - |