. Author manuscript; available in PMC: 2023 Feb 10.

Published in final edited form as: Sci Transl Med. 2022 Nov 16;14(671):eabl7646. doi: 10.1126/scitranslmed.abl7646

Table 1.

Demographic summary for included participants.

Participant Demographics	APOE ε4 – (n=223)	APOE ε4 + (n=127)	p-value

Age, years	70.2 (7.9)	68.9 (8.3)	t = −1.43, p=0.15
Male, n (%)	103 (46.2)	52 (41.0)	χ²=0.70, p=0.40
Education, years	16.3 (2.4)	16.3 (2.3)	t = −0.07, p=0.95
CDR > 0, n (%)	18 (8.1)	27 (21.2)	χ²=11.42, p=0.0007
CDR = 0.5	14 (6.3)	22 (17.3)
CDR > 0.5	4 (1.8)	5 (4.0)
CDR Sum of Boxes	0.25 (1.04)	0.65 (1.52)	t = 2.96, p=0.003
MMSE	29.0 (1.7)	28.5 (2.5)	t = − 2.30, p=0.02
White, n (%)	200 (89.7)	110 (86.6)	χ² =0.48, p=0.49
Tau PET +, n (%)	85 (38.1)	64 (50.4)	χ² =6.34, p=0.01
Aβ PET +, n (%)	45 (20.2)	61 (48.0)	χ² =26.56, p<0.0001
Aβ Summary SUVR	1.12 (0.50)	1.49 (0.73)	t = 5.56, p<0.0001
Tau Summary SUVR	1.24 (0.31)	1.38 (0.41)	t = 3.47, p=0.0006

Mean (standard deviation) unless otherwise noted.

APOE = apolipoprotein E; CDR = Clinical Dementia Rating; Aβ = amyloid-beta.