Fig. 3.

Representation of the hazard functions considered in the simulation study for both arms where the current HRQoL true value is set to its theoretical mean, i.e., $\lambda \left(t|arm,\mathbb{E},\left(\left(Y^{\star },(,t\right)\right)\right)={\lambda }_0(t)exp\left\{{\gamma }_1,,a,r,m,+,\alpha ,,\left({\beta }_0,+,{\beta }_1,t,+,{\beta }_2,\left\{a,r,m,\times ,t\right\}\right)\right\}$ where λ₀(t) = ϕt^ϕ − 1 exp(γ₀) with ϕ and exp(γ₀) the shape and scale parameters, respectively, according to t with t the time in months and arm the treatment arm indicator. HRQoL, health-related quality of life