. 2023 Feb 10;23:36. doi: 10.1186/s12874-023-01846-3

Table 1.

Main results of the LMM and JM fitted to the clinical trial data

	HRQoL score trajectory								Risk of dropout
	Time effect				Arm-by-time interaction effect				Arm effect		Association with HRQoL
	LMM		JM		LMM		JM		JM		JM
	${\hat{β}}_{1}$ [95% CI]	p	${\hat{β}}_{1}$ [95% CI]	p	${\hat{β}}_{2}$ [95% CI]	p	${\hat{β}}_{2}$ [95% CI]	p	${\hat{γ}}_{1}$ [95% CI]	p	$\hat{α}$ [95% CI]	p
GLOBAL HEALTH STATUS/HRQoL
Global health status/HRQoL	0.63 [− 0.17; 1.42]	0.121	0.31 [− 0.45; 1.07]	0.420	1.18 [0.25; 2.10]	0.013	1.19 [0.34; 2.03]	0.006	−0.43 [− 0.72; − 0.15]	0.003	− 0.029 [− 0.041; − 0.016]	< 10⁻⁴
FUNCTIONAL SCALES
Physical functioning	− 0.33 [− 1.17; 0.51]	0.439	− 0.77 [− 1.68; 0.15]	0.101	0.64 [− 0.38; 1.66]	0.222	0.86 [− 0.12; 1.85]	0.086	− 0.66 [− 0.95; − 0.37]	< 10⁻⁴	−0.028 [− 0.036; − 0.020]	< 10⁻⁴
Role functioning	0.80 [− 0.38; 1.98]	0.183	0.27 [− 0.93; 1.46]	0.663	1.10 [− 0.27; 2.47]	0.116	1.25 [− 0.08; 2.57]	0.065	− 0.57 [− 0.86; − 0.29]	< 10⁻⁴	− 0.018 [− 0.024; − 0.012]	< 10⁻⁴
Social functioning	0.11 [− 0.92; 1.15]	0.831	− 0.35 [− 1.44; 0.75]	0.533	1.15 [− 0.07; 2.37]	0.065	1.32 [0.09; 2.55]	0.036	− 0.57 [− 0.84; − 0.29]	< 10⁻⁴	−0.017 [− 0.022; − 0.012]	< 10⁻⁴
SYMPTOM SCALES
Fatigue	− 1.30 [− 2.35; − 0.24]	0.016	−0.78 [− 1.84; 0.28]	0.148	−0.51 [− 1.76; 0.74]	0.422	− 0.72 [− 1.90; 0.47]	0.235	−0.63 [− 0.91; − 0.35]	< 10⁻⁴	0.019 [0.012; 0.026]	< 10⁻⁴
Pain	−2.47 [−3.54; − 1.40]	< 10⁻³	−1.99 [− 3.01; − 0.98]	< 10⁻³	−1.01 [− 2.21; 0.19]	0.098	−0.88 [− 2.00; 0.24]	0.125	− 0.50 [− 0.77; − 0.22]	< 10⁻³	0.017 [0.007; 0.026]	< 10⁻³

HRQoL Health-related quality of life, JM Joint model, LMM Linear mixed model, CI Confidence interval