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. 2023 Feb 9;21:99. doi: 10.1186/s12967-023-03961-7

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© The Author(s) 2023

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 3 — Osteosarcoma was attributed to complicated regulation of abnormal signal pathways during development. A Hierarchical cluster dendrogram of identified co-expressed genes in modules in 12 MSCs, 3 osteoblasts, and 84 OS samples (GSE33383). B Clustering tree based on the module eigengenes of modules. C Heatmap of the correlation between hub genes and cell types. D, E, F Enrichment of BioPlanet signal pathway in MEgreen, MEblue, and MEgrey modules. G, H The correlation analysis between MSCs and osteoblast, as well as MSCs and osteoblast by Pearson method. I The connections of atypical signal pathways in ConsensusPathDB datasets