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. 2023 Feb 9;15:8. doi: 10.1186/s13073-023-01154-x

Fig. 4.

Fig. 4

HLA-I allele-specific expression loss and poor outcomes to anti-PD-1 immunotherapy treatment for metastatic melanoma. Extensive HLA-I ASE loss was found in melanoma cohort pre- and on-treatment with Nivolumab. Heterozygous cases are those with heterozygous genotypes for all the three HLA-I genes