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. 2023 Feb 10;17:7. doi: 10.1186/s40246-023-00451-1

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© The Author(s) 2023

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 1 — The delta score (DS) pitfall: discrepancy between SpliceAI’s DS and SpliceAI raw scores (RS). SpliceAI-visual outputs of SCN1A deep intronic variant displayed in IGV. Above: SpliceAI raw scores for the reference allele of SCN1A; below: SpliceAI RS for the pathogenic deep intronic variant NM_001165963.4(SCN1A):c.4002 + 2461 T > C functionally attested to cause the retention of an intronic retention of 64pb[REF]. Orange: acceptor site prediction; Blue: donor site prediction. The variant position is highlighted in yellow