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. 2023 Feb 10;23:138. doi: 10.1186/s12885-023-10559-1

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© This is a U.S. Government work and not under copyright protection in the US; foreign copyright protection may apply 2023

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Fig. 6 — CCND1 upregulation through GDNF-RET signaling. A UCSC genome browser data showing EGR1 binding motif located on the CCND1 promoter. B CCND1 mRNA levels after 1 μM TAM treatment showing increased transcription in the presence of rGDNF after 2, 3, and 12 h. C ChIP-qPCR data showing increased EGR1 binding to the CCND1 promoter. Student’s paired T-Test was used for statistical analyses. * p < 0.05, *** p < 0.0005