Table 3.

Mean change from baseline (week 2) fecal bacterial alpha diversity indices of adult dogs supplemented with GNU100 during and after metronidazole treatment

	ΔBL1-4		ΔBL-5		ΔBL-6		ΔBL-8			P-value
Item	CTRL2	TRT	CTRL	TRT	CTRL	TRT	CTRL	TRT	SEM3	Treatment	Time	Treatment*Time
Faith’s PD	−2.16	−1.73	−0.78	0.15	−0.88	0.09	−0.58	0.17	0.53	0.0244	0.0009	0.9380
Shannon Index	−0.77	−0.79	−0.38	−0.28	−0.17	−0.22	−0.13	−0.08	0.13	0.7692	<0.0001	0.8564
Pielou evenness	−0.03	−0.04	−0.02	−0.02	−0.01	−0.02	0.00	0.00	0.02	0.2637	0.0982	0.9693
Observed ASV	−72.04	−69.92	−37.58	−14.08	−20.04	−5.92	−22.76	−10.25	10.35	0.0446	<0.0001	0.6951

¹∆BL, change from baseline.

²CTRL, kibble diet only; TRT, kibble diet top dressed with GNU100.

³SEM, pooled standard errors of the means.