Table 4.

Mean change from baseline (week 2) fecal bacterial abundance (log DNA/gram feces) of adult dogs supplemented with GNU100 during and after metronidazole treatment

	ΔBL1-4		ΔBL-5		ΔBL-6		ΔBL-8			P-value
Item	CTRL2	TRT	CTRL	TRT	CTRL	TRT	CTRL	TRT	SEM3	Treatment	Time	Trt*Time
Total bacteria	−0.21	−0.27	−0.05	−0.13	−0.04	−0.08	−0.05	−0.02	0.05	0.1452	<0.0001	0.3990
Blautia	−1.38	−1.12	0.05	0.16	0.01	0.17	0.10	0.09	0.17	0.2799	<0.0001	0.8811
Fusobacterium	−1.32	−1.03	−0.63	0.07	−0.34	0.28	−0.66	0.21	0.21	<0.0001	<0.0001	0.4236
Turicibacter	−0.29	−0.53	0.23	−0.11	0.24	−0.03	0.23	−0.13	0.12	0.0007	<0.0001	0.9541
Streptococcus	1.16	1.85	−0.20	0.93	−0.64	0.62	−0.45	−0.21	0.61	0.0312	0.0052	0.7608
Clostridium hiranonis	−4.72	−5.17	−0.56	−1.89	−0.07	0.14	0.03	0.07	0.43	0.5896	<0.0001	NA4
Escherichia coli	2.39	2.39	1.31	1.35	−0.49	0.96	0.45	−0.27	0.61	0.5924	0.0002	NA
Faecalibacterium	−0.96	−0.96	0.32	0.22	0.14	0.19	−0.14	−0.06	0.23	0.9501	<0.0001	NA

¹∆BL, change from baseline.

²CTRL, kibble diet only; TRT, kibble diet top dressed with GNU100.

³SEM, pooled standard errors of the means.

⁴NA, not normal data, requiring nonparametric statistical analysis.