Table 6.

Mean change from baseline (week 2) fecal bile acid (BA) percentages of adult dogs supplemented with GNU100 during and after metronidazole treatment

	ΔBL1-4		ΔBL-5		ΔBL-6		ΔBL-8			P-value
Item	CTRL2	TRT	CTRL	TRT	CTRL	TRT	CTRL	TRT	SEM3	Treatment	Time	Trt*Time
Primary BA	59.0	65.2	27.7	31.1	−2.9	−2.9	−3.9	−2.8	6.66	0.5593	<0.0001	0.9640
CA4	52.0	56.1	23.9	27.2	−2.7	−2.1	−3.5	−2.3	5.76	0.5529	<0.0001	0.9871
CDCA	7.2	9.1	3.8	4.0	−0.1	−0.7	−0.5	−0.7	1.19	0.6902	<0.0001	0.7473
Secondary BA	−59.0	−65.2	−27.7	−31.1	2.9	2.9	3.9	2.8	6.66	0.5593	<0.0001	0.9640
LCA	−14.8	−20.8	−9.2	−8.5	0.3	2.5	1.6	0.1	3.24	0.7427	<0.0001	NA5
DCA	−43.6	−44.3	−21.9	−22.8	0.6	−0.3	1.9	3.3	5.16	0.9383	<0.0001	0.9943
UDCA	−0.3	−0.3	3.4	0.1	2.0	0.4	0.8	−0.6	0.71	0.0032	0.0276	0.2516

¹∆BL, change from baseline.

²CTRL, kibble diet only; TRT, kibble diet top dressed with GNU100.

³SEM, pooled standard errors of the means.

⁴CA, cholic acid; CDCA, chenodeoxycholic acid; LCA, lithocholic acid; DCA, deoxycholic acid; UDCA, ursodeoxycholic acid.

⁵NA, not normal data, requiring nonparametric statistical analysis.